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ALK Rabbit Polyclonal Antibody (CAB0766)

SKU:
CAB0766
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 1 Anti-ALK Antibody CAB0766
  • Cell Biology Antibodies 1 Anti-ALK Antibody CAB0766
  • Cell Biology Antibodies 1 Anti-ALK Antibody CAB0766
€139 - €419
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Description

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ALK Rabbit Polyclonal Antibody (CAB0766)

The Anti-ALK Antibody (CAB0766) is a high-quality polyclonal antibody designed for research targeting ALK, a receptor protein involved in cell growth and division. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the ALK protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent tool for studies in cancer biology and drug development.ALK, also known as anaplastic lymphoma kinase, is a key player in signaling pathways that regulate cell proliferation and survival. Dysregulation of ALK has been implicated in various cancers, including anaplastic large cell lymphoma and non-small cell lung carcinoma.

Research on ALK is essential for understanding the molecular mechanisms driving these diseases and for identifying potential therapeutic targets.This Anti-ALK Antibody is a valuable resource for investigating the role of ALK in cancer progression and for developing targeted therapies that exploit ALK signaling pathways. Its high specificity and sensitivity make it an indispensable tool for researchers working in oncology and molecular biology. By using this antibody, scientists can gain deeper insights into the intricate biology of ALK and its implications for cancer treatment strategies.

Product Name:ALK Rabbit Polyclonal Antibody
SKU:CAB0766
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1521-1620 of human ALK (NP_004295.2).
Sequence:PIAK KEPH DRGN LGLE GSCT VPPN VATG RLPG ASLL LEPS SLTA NMKE VPLF RLRH FPCG NVNY GYQQ QGLP LEAA TAPG AGHY EDTI LKSK NSMN QPGP
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IF/ICC,1:50 - 1:100
Synonyms:ALK1; CD246; NBLST3; ALK
Positive Sample:PC-3,Mouse testis
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Single-pass type I membrane protein.
Calculated MW:176kDa
Observed MW:140kDa/220kDa

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).

Purification Method:Affinity purification
Gene ID:238
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from SH-SY5Y, using ALK Rabbit pAb (CAB0766) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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