The Phospho-ABL1 (Y412) Polyclonal Antibody (CABP0303) is a valuable tool for researchers studying ABL1, a non-receptor tyrosine kinase involved in cell signaling and regulation. This antibody, produced in rabbits, has been rigorously tested and validated for use in Western blot applications with human samples. It specifically binds to the phosphorylated form of ABL1 at tyrosine 412, allowing for precise detection and analysis in various cell types.ABL1 is a key player in cellular processes such as cell growth, differentiation, and survival, making it a crucial target for research in cancer biology and drug development. Phosphorylation of ABL1 at tyrosine 412 is known to regulate its activity, affecting downstream signaling pathways and cellular functions.
By targeting this specific phosphorylation site, researchers can gain insights into the role of ABL1 in cancer progression, drug resistance, and other disease mechanisms.Overall, the Phospho-ABL1 (Y412) Polyclonal Antibody is a powerful tool for investigating the complex functions of ABL1 in cancer and other diseases, shedding light on potential therapeutic targets and treatment strategies. Its high specificity and sensitivity make it a valuable asset for researchers working in the fields of oncology, cell biology, and drug discovery.
Product Name:
Phospho-ABL1-Y412 Rabbit Polyclonal Antibody
SKU:
CABP0303
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around Y412 of human ABL1 (NP_009297.2).
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.
Purification Method:
Affinity purification
Gene ID:
25
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma using Phospho-c-Abl-Y412 Rabbit pAb (CABP0303).Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
