The PHLPP1 Polyclonal Antibody (CAB9542) is a valuable tool for research involving PHLPP1, a phosphatase enzyme that plays a critical role in regulating cell growth, survival, and metabolism. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It specifically recognizes the PHLPP1 protein, allowing for the detection and analysis of PHLPP1 expression in various cell types.PHLPP1 is known for its tumor-suppressive functions, making it a promising target for cancer research. By dephosphorylating key signaling molecules, PHLPP1 helps to control cell proliferation and survival, making it a potential target for therapeutic interventions in cancer treatment.
Understanding the role of PHLPP1 in cell signaling pathways is crucial for developing targeted therapies that can effectively inhibit tumor growth and progression.Overall, the PHLPP1 Polyclonal Antibody is a valuable tool for researchers studying cell signaling, cancer biology, and therapeutic interventions targeting PHLPP1. Its specificity and high reactivity make it ideal for use in a variety of experimental settings, providing valuable insights into the functions of PHLPP1 in health and disease.
Product Name:
PHLPP1 Rabbit Polyclonal Antibody
SKU:
CAB9542
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1160-1428 of human PHLPP1 (NP_919431.2).
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
Purification Method:
Affinity purification
Gene ID:
23239
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PHLPP1 Rabbit pAb (CAB9542) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
