PHLDA1 Antibody (PACO55230)
- SKU:
- PACO55230
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
PHLDA1 Antibody (PACO55230)
The PHLDA1 Polyclonal Antibody (PACO55230) is a key tool for researchers studying PHLDA1, a protein involved in cell growth and apoptosis. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By targeting the PHLDA1 protein, this antibody enables precise detection and analysis in various types of cells, making it an essential tool for studies in cancer biology and developmental biology.PHLDA1, also known as Pleckstrin Homology-Like Domain Family A Member 1, plays a crucial role in regulating cell growth and programmed cell death.
Its involvement in these processes makes it a promising target for research into cancer therapies and understanding developmental disorders. By delving into the function of PHLDA1, researchers can gain valuable insights into the mechanisms underlying these conditions, paving the way for novel therapeutic strategies and interventions.
| Antibody Name: | PHLDA1 Antibody (PACO55230) |
| Antibody SKU: | PACO55230 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Pleckstrin homology-like domain family A member 1 protein (1-138AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO55230 at dilution of 1: 100. |
 | Immunofluorescence staining of HepG2 cells with PACO55230 at 1: 133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized tissue using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation. |
| Synonyms: | Pleckstrin homology-like domain family A member 1 (Apoptosis-associated nuclear protein) (Proline- and glutamine-rich protein) (PQ-rich protein) (PQR protein) (Proline- and histidine-rich protein) (T-cell death-associated gene 51 protein), PHLDA1, PHRIP TDAG51 |
| UniProt Protein Function: | PHLDA1: Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.Protein type: Nucleolus; ApoptosisChromosomal Location of Human Ortholog: 12q15Cellular Component: cytosolMolecular Function: protein bindingBiological Process: G2/M transition of mitotic cell cycle |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8WV24 |
| NCBI GenInfo Identifier: | 229463035 |
| NCBI Gene ID: | 22822 |
| NCBI Accession: | Q8WV24.4 |
| UniProt Secondary Accession: | Q8WV24,Q15184, Q2TAN2, Q9NZ17, A1A4G9 |
| UniProt Related Accession: | Q8WV24 |
| Molecular Weight: | 45,016 Da |
| NCBI Full Name: | Pleckstrin homology-like domain family A member 1 |
| NCBI Synonym Full Names: | pleckstrin homology like domain family A member 1 |
| NCBI Official Symbol: | PHLDA1Â Â |
| NCBI Official Synonym Symbols: | PHRIP; TDAG51; DT1P1B11Â Â |
| NCBI Protein Information: | pleckstrin homology-like domain family A member 1 |
| UniProt Protein Name: | Pleckstrin homology-like domain family A member 1 |
| UniProt Synonym Protein Names: | Apoptosis-associated nuclear protein; Proline- and glutamine-rich protein; PQ-rich protein; PQR protein; Proline- and histidine-rich protein; T-cell death-associated gene 51 protein |
| Protein Family: | Pleckstrin homology-like domain family |
| UniProt Gene Name: | PHLDA1Â Â |
| UniProt Entry Name: | PHLA1_HUMAN |
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