The PHLDA1 Polyclonal Antibody (PAC022074) is a valuable tool for researchers studying PHLDA1, a gene involved in cell growth and apoptosis. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in various applications, including Western blot and immunohistochemistry.PHLDA1, also known as pleckstrin homology-like domain family A member 1, has been implicated in regulating cell proliferation and programmed cell death. Its role in these processes makes it a key target for investigating cancer development and progression.
By using this antibody to detect and analyze PHLDA1 expression in different cell types, researchers can gain valuable insights into its functions and potential therapeutic applications.Furthermore, understanding the mechanisms underlying PHLDA1 activity is essential for developing targeted therapies for cancer and other diseases associated with dysregulated cell growth and survival. The PHLDA1 Polyclonal Antibody provides a reliable tool for researchers to advance their studies in this important area of research.
Antibody Name:
PHLDA1 Antibody (PACO22074)
Antibody SKU:
PACO22074
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from internal of human PHLA1.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from RAW264.7 cells, using PHLA1 antibody.
Background:
Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.
Synonyms:
Pleckstrin homology-like domain family A member 1; T-cell death-associated gene 51 protein; Apoptosis-associated nuclear protein; Proline- and histidine-rich protein; Proline- and glutamine-rich protein
UniProt Protein Function:
PHLDA1: Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.Protein type: Nucleolus; ApoptosisChromosomal Location of Human Ortholog: 12q15Cellular Component: cytosolMolecular Function: protein bindingBiological Process: G2/M transition of mitotic cell cycle
UniProt Protein Details:
NCBI Summary:
This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008]
