The PHKG2 Polyclonal Antibody (CAB14040) is a valuable tool for researchers studying PHKG2, a critical enzyme involved in the regulation of glycogen metabolism and energy production. This antibody, raised in rabbits, has been extensively tested and validated for use in various applications, including Western blotting and immunohistochemistry.PHKG2, a key player in the cell's energy production pathway, is essential for maintaining proper glycogen levels and ensuring optimal cellular function. Dysregulation of PHKG2 has been linked to metabolic disorders such as glycogen storage diseases and even cancer development.
By targeting PHKG2 with this polyclonal antibody, researchers can gain insights into its role in these diseases and potentially identify new therapeutic targets.With its high specificity and sensitivity, the PHKG2 Polyclonal Antibody (CAB14040) is a valuable tool for researchers in the fields of metabolism, biochemistry, and oncology. Its ability to detect and analyze PHKG2 protein expression in various cell types makes it an essential reagent for studies aimed at understanding the biological functions of PHKG2 and its potential implications in disease pathology.
Product Name:
PHKG2 Rabbit Polyclonal Antibody
SKU:
CAB14040
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 237-406 of human PHKG2 (NP_000285.1).
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Purification Method:
Affinity purification
Gene ID:
5261
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PHKG2 antibody (CAB14040) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
