PHKA1 Rabbit Polyclonal Antibody (CAB15700)
- SKU:
- CAB15700
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | PHKA1 Rabbit Polyclonal Antibody |
SKU: | CAB15700 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 600-820 of human PHKA1 (NP_001116142.1). |
Sequence: | QTGK LSEF LTTS CCTH LSFM DPGP EGKL YSED YDDN YDYL ESGN WMND YDST SHAR CGDE VARY LDHL LAHT APHP KLAP TSQK GGLD RFQA AVQT TCDL MSLV TKAK ELHV QNVH MYLP TKLF QASR PSFN LLDS PHPR QENQ VPSV RVEI HLPR DQSG EVDF KALV LQLK ETSS LQEQ ADIL YMLY TMKG PDWN TELY NERS ATVR ELLT ELYG KVGE I |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | PHKA; PHKA1 |
Positive Sample: | U-87MG,Jurkat,HeLa,Mouse heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasmic side, Lipid-anchor. |
Calculated MW: | 137kDa |
Observed MW: | 137kDa |
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. A pseudogene has been found on chromosome 1.
Purification Method: | Affinity purification |
Gene ID: | 5255 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |