The PHKA1/PHKA2 Polyclonal Antibody (PACO04584) is a valuable tool for researchers studying the PHKA1 and PHKA2 proteins, which are involved in glycogen metabolism and are associated with glycogen storage diseases. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications. By targeting the PHKA1/PHKA2 proteins, this antibody enables precise detection and analysis in a variety of cell types, making it an essential reagent for studies in metabolic disorders and related conditions.The PHKA1 and PHKA2 proteins are key players in the regulation of glycogen synthesis and breakdown, essential processes for energy storage and utilization in the body.
Dysregulation of these proteins can lead to abnormal glycogen accumulation and result in serious health consequences, including muscle weakness, liver dysfunction, and other metabolic disorders. Research on PHKA1 and PHKA2 is crucial for understanding the underlying mechanisms of glycogen metabolism and developing targeted therapies for glycogen storage diseases and related disorders.By using the PHKA1/PHKA2 Polyclonal Antibody (PACO04584), researchers can uncover new insights into the roles of these proteins in health and disease, paving the way for innovative treatments and interventions in the field of metabolic research.
Antibody Name:
PHKA1/PHKA2 Antibody
Antibody SKU:
PACO04584
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IF
Recommended Dilutions:
WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the N-terminal region of human PHKA1/2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
PHKA1; PHKA; Phosphorylase b kinase regulatory subunit alpha; skeletal muscle isoform; Phosphorylase kinase alpha M subunit; PHKA2; PHKLA; PYK; Phosphorylase b kinase regulatory subunit alpha, liver isoform; Phosphorylase kinase alpha L sub
NCBI Summary:
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. A pseudogene has been found on chromosome 1.[provided by RefSeq, Feb 2010]
