The PHC2 Polyclonal Antibody (CAB14727) is a valuable tool for researchers studying PHC2, a protein involved in epigenetic regulation and cancer development. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By binding to the PHC2 protein, this antibody enables the detection and analysis of PHC2 levels in different cell types, making it an ideal choice for studies focused on epigenetics and cancer research.PHC2, a member of the polycomb group proteins, is known to play a crucial role in chromatin remodeling and transcriptional regulation. Dysregulation of PHC2 has been implicated in various types of cancer, making it a promising target for therapeutic interventions.
Investigating the function of PHC2 can provide valuable insights into the underlying mechanisms of tumorigenesis and may lead to the development of novel anti-cancer strategies.In summary, the PHC2 Polyclonal Antibody (CAB14727) offers researchers a reliable tool for investigating the role of PHC2 in epigenetic regulation and cancer biology. By understanding the functions of PHC2, researchers can potentially identify new targets for cancer treatment and improve our knowledge of the molecular pathways involved in cancer development.
Product Name:
PHC2 Rabbit Polyclonal Antibody
SKU:
CAB14727
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PHC2 (NP_004418.2).
In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1912
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PHC2 Rabbit pAb (CAB14727) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
