The PHC1 Polyclonal Antibody (CAB5843) is a valuable tool for researchers studying the PHC1 protein, a key player in the regulation of gene expression and cellular processes. This antibody, developed through rabbit immunization, exhibits high reactivity with human samples and is validated for use in Western blotting applications.PHC1, a component of the polycomb repressive complex 1 (PRC1), is involved in the epigenetic control of gene expression through chromatin remodeling.
Its dysregulation has been implicated in various diseases, including cancer and developmental disorders. By targeting PHC1 with this specific antibody, researchers can gain insights into its functions and molecular interactions in different cell types, paving the way for advancements in biomedical research and potential therapeutic strategies.
Product Name:
PHC1 Rabbit Polyclonal Antibody
SKU:
CAB5843
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 750-940 of human PHC1 (NP_004417.2).
This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein.
Purification Method:
Affinity purification
Gene ID:
1911
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PHC1 Antibody (CAB5843) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
