The PHB Polyclonal Antibody (CAB13526) is a valuable tool for researchers studying Prohibitin (PHB), a multifunctional protein implicated in various cellular processes such as cell proliferation, apoptosis, and mitochondrial function. The antibody is produced in rabbits and is specifically reactive with human samples, making it ideal for use in Western blot applications.Prohibitin is known to be involved in the regulation of cell cycle progression, DNA repair, and mitochondrial respiratory chain function. Dysregulation of PHB expression has been linked to cancer development, making it an important target for cancer research.
By binding to the PHB protein, this antibody enables researchers to detect and analyze its expression in different cell types, providing valuable insights into its role in cancer biology and other pathological conditions.Studying the function of Prohibitin with the help of this antibody can lead to a better understanding of its molecular mechanisms and potential therapeutic implications. By uncovering the regulatory pathways involving PHB, researchers may identify new targets for drug development and treatment strategies for cancer and other diseases related to mitochondrial dysfunction.
Product Name:
Prohibitin Rabbit Polyclonal Antibody
SKU:
CAB13526
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat,Monkey
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 73-272 of human Prohibitin (NP_002625.1).
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5245
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Prohibitin Rabbit pAb (CAB13526) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
