The PHAX Antibody (PAC011206) is a high-quality polyclonal antibody specifically designed for research involving PHAX, a crucial protein involved in RNA processing and export. The antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in applications such as Western blotting.PHAX plays a key role in the transport of small nucleolar RNAs (snoRNAs) from the nucleus to the cytoplasm, where they participate in various cellular processes like ribosome biogenesis. Research on PHAX is essential for understanding its function in gene expression regulation and its potential implications in diseases such as cancer and developmental disorders.
This antibody enables the detection and analysis of PHAX in various cell types, making it a valuable tool for scientists studying RNA processing, cell biology, and molecular genetics. By elucidating the roles of PHAX in cellular pathways, researchers can uncover new insights into gene regulation mechanisms and potentially identify novel therapeutic targets for various diseases.
phosphorylated adaptor for RNA export;PHAX;FLJ13193;RNUXA ;
UniProt Protein Function:
RNUXA: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation- independent manner. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA. Belongs to the PHAX family.Protein type: RNA-binding; Nuclear importChromosomal Location of Human Ortholog: 5q23.2Cellular Component: centrosome; cytosol; intracellular membrane-bound organelle; nucleoplasm; nucleusMolecular Function: protein bindingBiological Process: nuclear export; snRNA export from nucleus; snRNA transcription from RNA polymerase II promoter
