The PGR Polyclonal Antibody (CAB2105) is a valuable tool for researchers studying the progesterone receptor (PGR), a key protein involved in hormone signaling pathways. Raised in rabbits, this antibody is highly specific and reactive with human samples, making it an ideal choice for experiments in Western blotting and immunohistochemistry.The progesterone receptor plays a critical role in the female reproductive system, mediating the effects of progesterone on target tissues such as the uterus, mammary glands, and ovaries. Dysregulation of PGR signaling has been linked to various gynecological cancers and reproductive disorders, making it an important target for therapeutic interventions.
By using the PGR Polyclonal Antibody (CAB2105), researchers can effectively detect and analyze PGR expression in different cell types and tissues, shedding light on its function and potential implications in disease pathology. This antibody is a valuable tool for studies in endocrinology, reproductive biology, and cancer research, providing valuable insights into the role of PGR in health and disease.
Product Name:
Progesterone Receptor Rabbit Polyclonal Antibody
SKU:
CAB2105
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 834-933 of human Progesterone Receptor (NP_000917.3).
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap.
Purification Method:
Affinity purification
Gene ID:
5241
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse lung, using Progesterone Receptor antibody (CAB2105) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
