The PGR Polyclonal Antibody (CAB0321) is an essential tool for researchers studying the progesterone receptor (PGR), a key regulator of female reproductive function. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It specifically targets the PGR protein, enabling accurate detection and analysis in a variety of cell types.The progesterone receptor plays a crucial role in mediating the effects of progesterone in the female reproductive system, influencing processes such as ovulation, implantation, and pregnancy maintenance. Dysregulation of PGR signaling has been implicated in various reproductive disorders, including infertility, endometriosis, and certain types of cancer.
As such, this antibody is invaluable for research into these conditions, providing insights into PGR function and potential therapeutic strategies.By using the PGR Polyclonal Antibody (CAB0321), researchers can delve deeper into the mechanisms governing progesterone receptor activity, paving the way for new advancements in reproductive medicine and women's health. Its exceptional specificity and sensitivity make it a trusted reagent for exploring the intricate functions of PGR and its implications in reproductive biology and disease pathology.
Product Name:
Progesterone Receptor Rabbit Polyclonal Antibody
SKU:
CAB0321
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human Progesterone Receptor (NP_000917.3).
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap.
Purification Method:
Affinity purification
Gene ID:
5241
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Progesterone Receptor Rabbit pAb (CAB0321) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
