The PGPEP1 Polyclonal Antibody (PACO11202) is a powerful tool for researchers studying PGPEP1, a protease involved in various physiological processes, including immune regulation and inflammation. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting PGPEP1 in human samples, making it an essential tool for Western blot applications. By targeting the PGPEP1 protein, researchers can gain insights into its functions and roles in different cell types, particularly in the fields of immunology and cancer research.
PGPEP1, also known as a prolylglycine peptidase, is a crucial enzyme that regulates peptide metabolism and turnover, impacting diverse biological pathways. Its involvement in immune regulation and inflammatory responses underscores its importance in various disease contexts, such as cancer and autoimmune disorders. By unraveling the molecular mechanisms of PGPEP1, researchers can uncover potential therapeutic targets for treating immune-related diseases and developing innovative treatment strategies.
PGPEP1: Removes 5-oxoproline from various penultimate amino acid residues except L-proline. Belongs to the peptidase C15 family.Protein type: Protease; EC 3.4.19.3Chromosomal Location of Human Ortholog: 19p13.11Cellular Component: cytosolBiological Process: proteolysis
UniProt Protein Details:
NCBI Summary:
The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]
