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PGP9.5 Monoclonal Antibody [P3D9AT] (CPAB0520)

SKU:
CPAB0520
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2a
Clone:
P3D9AT
Applications:
WB
ELISA
IHC
$179
Frequently bought together:

Description

system_update_alt Datasheet

PGP9.5 Monoclonal Antibody [P3D9AT] (CPAB0520)

The PGP9.5 Polyclonal Antibody (CPAB0520) is a valuable tool for researchers studying PGP9.5, a marker for neuronal cells and a key enzyme in the ubiquitin-proteasome pathway. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting and immunohistochemistry.PGP9.5, also known as ubiquitin carboxyl-terminal hydrolase 1 (UCHL1), is involved in protein turnover and degradation within cells, making it a crucial player in maintaining cellular homeostasis.

Its expression is often dysregulated in neurodegenerative diseases and cancer, highlighting its importance in these pathological conditions. By targeting PGP9.5 with this antibody, researchers can gain insights into its expression patterns and functions in different cell types, particularly in studies related to neurobiology and oncology. This antibody is an essential tool for investigating the role of PGP9.5 in various disease states and potential therapeutic interventions.

Product Name:PGP9.5 Antibody
Product Sku:CPAB0520
Size:5μg
Host Species:Mouse
Immunogen:Anti-human PGP9.5 mAb is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PGP9.5 amino acids 1-223 purified from Ecoli.
Clone:P3D9AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA, Immunohistochemistry
Purification Method:PGP95 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2a
Background:UCHL1 (PGP9.5) belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product (PGP9.5) is a neuron specific protein, structurally and immunologically distinct from neuron specific enolase. Human UCHL1 and UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein''s resistance to degradation in the proteasome. The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons and nerve fibers at all levels of the central and peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia and leydig cells of the testis, in ova and in some cells of both the pregnant and non pregnant corpus luteum. A point mutation (I93M) in UCHL1 is implicat
Synonyms:Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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