PGP Antibody (PACO46106)
- SKU:
- PACO46106
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PGP Antibody (PACO46106)
The Pgp Antibody (PAC046106) offered by Assay Genie is a high-quality polyclonal antibody designed for research involving P-Glycoprotein (Pgp), a cell surface protein known for its role in multi-drug resistance. The antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in various applications, including Western blotting.Pgp is a transmembrane protein that plays a crucial role in pumping drugs out of cells, reducing their effectiveness in treating diseases like cancer. Research into Pgp is important for understanding drug resistance mechanisms and developing strategies to overcome them.
The Pgp Antibody enables specific detection and analysis of Pgp protein levels in various cell types, making it a valuable tool for studying drug resistance in cancer and other diseases.With its specificity and sensitivity in detecting Pgp, the PAC046106 Antibody is a valuable resource for researchers exploring drug resistance mechanisms and developing novel therapies to combat multi-drug resistance in cancer and other diseases. Its application in immunology and cancer research makes it a versatile tool for studies focused on understanding drug transport mechanisms and developing effective treatment strategies.
| Antibody Name: | PGP Antibody (PACO46106) |
| Antibody SKU: | PACO46106 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Glycerol-3-phosphate phosphatase protein (140-300AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO46106 at dilution of 1:100. |
 | Immunofluorescent analysis of MCF-7 cells using PACO46106 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP (By similarity). |
| Synonyms: | Glycerol-3-phosphate phosphatase (G3PP) (EC 3.1.3.21) (Aspartate-based ubiquitous Mg(2+)-dependent phosphatase) (AUM) (EC 3.1.3.48) (Phosphoglycolate phosphatase) (PGP), PGP |
| UniProt Protein Function: | PGP: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 3.1.3.48; EC 3.1.3.18; Phosphatase (non-protein) Chromosomal Location of Human Ortholog: 16p13.3 Molecular Function:phosphoglycolate phosphatase activity; magnesium ion binding; protein tyrosine phosphatase activity Biological Process: dephosphorylation; carbohydrate metabolic process |
| UniProt Code: | A6NDG6 |
| NCBI GenInfo Identifier: | 166987826 |
| NCBI Gene ID: | 283871 |
| NCBI Accession: | A6NDG6.1 |
| UniProt Related Accession: | A6NDG6 |
| Molecular Weight: | 34,006 Da |
| NCBI Full Name: | Phosphoglycolate phosphatase |
| NCBI Synonym Full Names: | phosphoglycolate phosphatase |
| NCBI Official Symbol: | PGPÂ Â |
| NCBI Protein Information: | phosphoglycolate phosphatase; PGPase |
| UniProt Protein Name: | Phosphoglycolate phosphatase |
| Protein Family: | Glycerol-3-phosphate phosphatase |
| UniProt Gene Name: | PGPÂ Â |
| UniProt Entry Name: | PGP_HUMAN |
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