The PGM3 Polyclonal Antibody (CAB15699) is a valuable tool for researchers studying PGM3, a key enzyme involved in the synthesis of UDP-GlcNAc, an essential sugar molecule in various biological processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically targeting the PGM3 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in glycobiology and metabolic research.PGM3 is known for its crucial role in the hexosamine biosynthetic pathway, which is responsible for producing UDP-GlcNAc, a precursor for glycosylation reactions essential for protein modification and cellular signaling.
Dysregulation of PGM3 has been linked to various diseases, including congenital disorders and metabolic syndromes, highlighting its significance in human health. Research into PGM3 function is vital for understanding the molecular mechanisms underlying these conditions and exploring potential therapeutic targets for their treatment.
Product Name:
PGM3 Rabbit Polyclonal Antibody
SKU:
CAB15699
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PGM3 (NP_056414.1).
This gene encodes a member of the phosphohexose mutase family. The encoded protein mediates both glycogen formation and utilization by catalyzing the interconversion of glucose-1-phosphate and glucose-6-phosphate. A non-synonymous single nucleotide polymorphism in this gene may play a role in resistance to diabetic nephropathy and neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
5238
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PGM3 Rabbit pAb (CAB15699) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
