The PGM3 Polyclonal Antibody (CAB15698) is a valuable tool for research involving PGM3, a key enzyme involved in the biosynthesis of nucleotide sugars. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the PGM3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential reagent for studies in glycobiology and metabolic research.PGM3 plays a crucial role in the synthesis of UDP-GlcNAc, a sugar nucleotide that serves as a substrate for glycosylation reactions.
Dysregulation of PGM3 activity has been linked to various metabolic disorders, making it a target of interest for investigating diseases like congenital disorders of glycosylation and immune system dysfunction. Understanding the role of PGM3 in nucleotide sugar metabolism is essential for developing therapies that target these pathways in relevant disease contexts.
Product Name:
PGM3 Rabbit Polyclonal Antibody
SKU:
CAB15698
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PGM3 (NP_056414.1).
This gene encodes a member of the phosphohexose mutase family. The encoded protein mediates both glycogen formation and utilization by catalyzing the interconversion of glucose-1-phosphate and glucose-6-phosphate. A non-synonymous single nucleotide polymorphism in this gene may play a role in resistance to diabetic nephropathy and neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
5238
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PGM3 Rabbit pAb (CAB15698) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
