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PGM1 Polyclonal Antibody

SKU:
CAB21540
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€129 - €359
Frequently bought together:

Description

PGM1 Polyclonal Antibody (CAB21540)

The PGM1 Polyclonal Antibody is a valuable tool for researchers studying the enzyme phosphoglucomutase 1 (PGM1), which plays a crucial role in carbohydrate metabolism. This antibody, raised in rabbits, specifically recognizes PGM1 in human samples and is validated for use in Western blot applications. By binding to PGM1, this antibody allows for the detection and analysis of the enzyme in various cell types, making it an ideal choice for studies in biochemistry and metabolic disorders.

PGM1 is involved in the conversion of glucose-1-phosphate to glucose-6-phosphate, a key step in both glycogen synthesis and glycolysis. Dysregulation of PGM1 activity has been linked to disorders such as glycogen storage disease type XIV and congenital disorders of glycosylation. By understanding the function and regulation of PGM1, researchers can gain insights into these conditions and potentially develop targeted treatments.

Product Name:PGM1 Polyclonal Antibody
Product Code:CAB21540
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:2000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Cellular Location:Cytoplasm

The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PGM1 (NP_002624.2).
Sequence:MVKIV TVKTQ AYQDQ KPGTS GLRKR VKVFQ SSANY AENFI QSIIS TVEPA QRQEA TLVVG GDGRF YMKEA IQLIA RIAAA NGIGR LVIGQ NGILS TPAVS CIIRK IKAIG GIILT ASHNP GGPNG DFGIK FNISN GGPAP EAITD KIFQI SKTIE EYAVC PDLKV DLGVL GKQQF DLENK FKPFT VEIVD SVEAY ATMLR SIFDF SALKE LLSGP NRLKI RIDAM HGVVG PYVKK ILCEE LGAPA NSAVN CVPLE DFGGH HPDPN LTYAA DLVET MKSGE HDFGA AFDGD GDRNM ILGKH
Synonyms:CDG1T, GSD14
Calculated MW:61kDa
Observed MW:Refer to figures

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