The pGlyrp4 Polyclonal Antibody (PAC028902) is a specialized tool for researchers studying pGlyrp4, a protein associated with innate immune responses and inflammatory processes. This antibody, generated in rabbits, is highly specific to human samples and has been extensively validated for use in Western blotting techniques. By binding to the pGlyrp4 protein, researchers can accurately detect and quantify its expression in various cell types, making it an invaluable resource for studies in immunology and infectious disease research.pGlyrp4, also known as peptidoglycan recognition protein 4, plays a crucial role in the recognition and clearance of bacterial pathogens, contributing to the body's defense mechanisms against microbial infections.
Its involvement in immune responses makes it a promising target for investigating conditions such as sepsis, inflammatory bowel disease, and other infectious disorders. By elucidating the function of pGlyrp4, researchers can potentially identify new therapeutic strategies for treating bacterial infections and related inflammatory conditions.
Antibody Name:
PGLYRP4 Antibody (PACO28902)
Antibody SKU:
PACO28902
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Peptidoglycan recognition protein 4 protein (18-317AA)
Immunohistochemistry of paraffin-embedded human skin tissue using PACO28902 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human gastric cancer using PACO28902 at dilution of 1:100.
Background:
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
Synonyms:
Peptidoglycan recognition protein 4 (Peptidoglycan recognition protein I-beta) (PGLYRPIbeta) (PGRP-I-beta) (Peptidoglycan recognition protein intermediate beta), PGLYRP4, PGRPIB
UniProt Protein Function:
PGLYRP4: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity. Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 1q21Molecular Function: peptidoglycan binding; peptidoglycan receptor activityBiological Process: defense response to Gram-positive bacterium; detection of bacterium
UniProt Protein Details:
NCBI Summary:
Summary: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
