| UniProt Protein Function: | PGLYRP4: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity. Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 1q21Molecular Function: peptidoglycan binding; peptidoglycan receptor activityBiological Process: defense response to Gram-positive bacterium; detection of bacterium |
| UniProt Protein Details: | |
| NCBI Summary: | Summary: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014] |
| UniProt Code: | Q96LB8 |
| NCBI GenInfo Identifier: | 143811439 |
| NCBI Gene ID: | 57115 |
| NCBI Accession: | Q96LB8.2 |
| UniProt Secondary Accession: | Q96LB8,Q3B822, Q3B823, Q5SY63, Q5SY64, Q9HD75, A8K838 |
| UniProt Related Accession: | Q96LB8 |
| Molecular Weight: | |
| NCBI Full Name: | Peptidoglycan recognition protein 4 |
| NCBI Synonym Full Names: | peptidoglycan recognition protein 4 |
| NCBI Official Symbol: | PGLYRP4Â Â |
| NCBI Official Synonym Symbols: | PGRPIB; SBBI67; PGRP-Ibeta; PGLYRPIbeta  |
| NCBI Protein Information: | peptidoglycan recognition protein 4 |
| UniProt Protein Name: | Peptidoglycan recognition protein 4 |
| UniProt Synonym Protein Names: | Peptidoglycan recognition protein I-beta; PGLYRPIbeta; PGRP-I-beta; Peptidoglycan recognition protein intermediate beta |
| Protein Family: | Peptidoglycan recognition protein |
| UniProt Gene Name: | PGLYRP4Â Â |
| UniProt Entry Name: | PGRP4_HUMAN |
