PGK1 Rabbit Monoclonal Antibody (CAB12686)
- SKU:
- CAB12686
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | PGK1 Rabbit Monoclonal Antibody |
SKU: | CAB12686 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PGK1 (P00558). |
Sequence: | MSLS NKLT LDKL DVKG KRVV MRVD FNVP MKNN QITN NQRI KAAV PSIK FCLD NGAK SVVL MSHL GRPD GVPM PDKY SLEP VAVE LKSL LGKD VLFL KDCV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | PGKA; MIG10; HEL-S-68p; PGK1 |
Positive Sample: | HeLa,HepG2,K-562,Mouse lung,Mouse brain,Rat ovary,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 45kDa |
Observed MW: | 45kDa |
The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome.
Purification Method: | Affinity purification |
Gene ID: | 5230 |
Clone Number: | ARC0700 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |