PGK1 Rabbit Polyclonal Antibody (CAB14039)
- SKU:
- CAB14039
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | PGK1 Rabbit Polyclonal Antibody |
SKU: | CAB14039 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-417 of human PGK1 (NP_000282.1). |
Sequence: | MSLS NKLT LDKL DVKG KRVV MRVD FNVP MKNN QITN NQRI KAAV PSIK FCLD NGAK SVVL MSHL GRPD GVPM PDKY SLEP VAVE LKSL LGKD VLFL KDCV GPEV EKAC ANPA AGSV ILLE NLRF HVEE EGKG KDAS GNKV KAEP AKIE AFRA SLSK LGDV YVND AFGT AHRA HSSM VGVN LPQK AGGF LMKK ELNY FAKA LESP ERPF LAIL GGAK VADK IQLI NNML DKVN EMII GGGM AFTF LKVL NNME IGTS LFDE EGAK IVKD LMSK AEKN GVKI TLPV DFVT ADKF DENA KTGQ ATVA SGIP AGWM GLDC GPES SKKY AEAV TRAK QIVW NGPV GVFE WEAF ARGT KALM DEVV KATS RGCI TIIG GGDT ATCC AKWN TEDK VSHV STGG GASL ELLE GKVL PGVD ALSN I |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 |
Synonyms: | PGKA; MIG10; HEL-S-68p; PGK1 |
Positive Sample: | U-251MG,HepG2,HeLa,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 45kDa |
Observed MW: | 45kDa |
The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome.
Purification Method: | Affinity purification |
Gene ID: | 5230 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |