The PGDH Rabbit Monoclonal Antibody (CAB5024) is a valuable tool for researchers studying PGDH, an important enzyme involved in the metabolism of prostaglandins and other lipid mediators. This antibody, developed using rabbit monoclonal technology, exhibits high specificity and sensitivity for human samples, making it ideal for use in various research applications such as Western blot and immunohistochemistry.PGDH, also known as 15-hydroxyprostaglandin dehydrogenase, plays a key role in the regulation of inflammation and pain signaling pathways by catalyzing the degradation of prostaglandins.
Dysregulation of PGDH activity has been implicated in various diseases including cancer, inflammatory disorders, and cardiovascular diseases. By targeting PGDH with this antibody, researchers can gain insights into the biochemical pathways involved in these conditions and potentially develop novel therapeutic strategies.In summary, the PGDH Rabbit Monoclonal Antibody (CAB5024) offers researchers a reliable tool for studying the role of PGDH in health and disease, enabling advancements in the fields of inflammation, pain management, and drug development.
Product Name:
15-PGDH/HPGD Rabbit Monoclonal Antibody
SKU:
CAB5024
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 50-151 of human 15-PGDH/HPGD (P15428).
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3248
Clone Number:
ARC1280
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using 15-PGDH/HPGD Rabbit mAb (CAB5024) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
