The PGC1 Alpha/Beta Rabbit Monoclonal Antibody (CAB19674) is a valuable tool for researchers studying the PGC1 family of transcriptional coactivators, known for their roles in regulating cellular metabolism and energy production. This antibody, produced specifically for use in humans, is ideal for applications such as Western blotting, immunohistochemistry, and immunofluorescence.PGC1 Alpha and Beta are key regulators of mitochondrial biogenesis and oxidative metabolism, making them essential for cells with high energy demands, such as muscle and brown adipose tissue. Dysregulation of PGC1 activity is associated with metabolic diseases, neurodegenerative disorders, and cancer, highlighting the importance of studying these proteins in various cellular contexts.
By targeting both PGC1 Alpha and Beta proteins, this rabbit monoclonal antibody enables researchers to investigate the roles of these coactivators in different biological processes, offering insights into potential therapeutic strategies for conditions related to energy metabolism and mitochondrial dysfunction. Its high specificity and sensitivity make it a valuable tool for advancing our understanding of PGC1 function in health and disease.
Antibody Name:
Anti-PGC1 alpha/beta Antibody
Antibody SKU:
CAB19674
Antibody Size:
20uL, 50uL, 100uL
Application:
WB
Reactivity:
Mouse, Rat
Host Species:
Rabbit
Immunogen:
A synthesized peptide derived from human PGC1 alpha/beta.
Application:
WB
Recommended Dilution:
WB 1:500 - 1:2000
Reactivity:
Mouse, Rat
Positive Samples:
Mouse liver, Rat heart
Immunogen:
A synthesized peptide derived from human PGC1 alpha/beta.
Purification Method:
Affinity purification
Storage Buffer:
Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:
IgG
Sequence:
Email for sequence
Gene ID:
10891/133522
Uniprot:
Q9UBK2/Q86YN6
Cellular Location:
Calculated MW:
113kDa
Observed MW:
113KDa
Western blot - PGC1 alpha/beta Rabbit mAb (CAB19674)
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
