PGC Antibody (PACO03211)
- SKU:
- PACO03211
- Product Type:
- Antibody
- Reactivity:
- Plant
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PGC Antibody (PACO03211)
The PGC Antibody (PACO3211) is a high-quality antibody designed for research involving Progastricsin (PGC), a precursor protein involved in the regulation of the digestive system. This polyclonal antibody, generated in rabbits, is specifically reactive against human samples and is validated for use in Western blot applications. By targeting the PGC protein, researchers can detect and analyze this important molecule in various cell types, making it a valuable tool for studies in gastrointestinal health and diseases.
PGC is a key player in the digestive process, serving as a precursor to pepsin, an enzyme involved in breaking down proteins in the stomach. Understanding the role of PGC in regulating digestive function is essential for exploring its potential as a therapeutic target for gastrointestinal disorders. The PGC Antibody provides researchers with a reliable tool for investigating the expression and function of PGC in both normal and diseased tissues, advancing our knowledge of digestive physiology and pathology.
| Antibody Name: | PGC Antibody |
| Antibody SKU: | PACO03211 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | WB |
| Recommended Dilutions: | |
| Species Reactivity: | Plants |
| Immunogen: | synthetic Peptide |
| Form: | Liquid |
| Storage Buffer: | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification Method: | Affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | PGC; Gastricsin; Pepsinogen C |
| UniProt Protein Function: | PGC: Hydrolyzes a variety of proteins. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Protease; Secreted; EC 3.4.23.3 Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: extracellular space Molecular Function:aspartic-type endopeptidase activity Biological Process: digestion; proteolysis |
| NCBI Summary: | This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009] |
| UniProt Code: | P20142 |
| NCBI GenInfo Identifier: | 129796 |
| NCBI Gene ID: | 5225 |
| NCBI Accession: | P20142.1 |
| UniProt Secondary Accession: | P20142,Q5T3D7, Q5T3D8, B4DVZ3, |
| UniProt Related Accession: | P20142 |
| Molecular Weight: | 40,600 |
| NCBI Full Name: | Gastricsin |
| NCBI Synonym Full Names: | progastricsin (pepsinogen C) |
| NCBI Official Symbol: | PGCÂ Â |
| NCBI Official Synonym Symbols: | PEPC; PGIIÂ Â |
| NCBI Protein Information: | gastricsin; pepsin C; pepsinogen C; preprogastricsin; pepsinogen group II |
| UniProt Protein Name: | Gastricsin |
| UniProt Synonym Protein Names: | Pepsinogen C |
| Protein Family: | Gastricsin |
| UniProt Gene Name: | PGCÂ Â |
| UniProt Entry Name: | PEPC_HUMAN |
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