The PGBD3 Polyclonal Antibody (PAC01192) is a vital tool for researchers studying PGBD3, a transposase protein that plays a role in genome diversification and evolution. This antibody, generated in rabbits, exhibits high specificity for human samples and is validated for use in Western blot analysis. Through its binding to the PGBD3 protein, researchers can accurately detect and analyze its expression in various cell types, making it a valuable asset for studies in genetics and evolutionary biology.PGBD3 is a unique transposase that has been linked to the mobilization of DNA elements within the genome, leading to genetic diversity and adaptation.
Understanding the function and regulation of PGBD3 is essential for unraveling its impact on genome stability and evolution. This antibody provides researchers with a reliable tool to investigate the role of PGBD3 in processes such as DNA rearrangement and gene expression, shedding light on its significance in genetic variability and evolutionary dynamics.
piggyBac transposable element derived 3;PGBD3;FLJ90201 ;
UniProt Protein Function:
PGBD3: Chromosomal Location of Human Ortholog: 10q11
UniProt Protein Details:
NCBI Summary:
This gene is a member of a small family of genes derived from piggyBac transposable elements. The encoded protein contains a zinc-ribbon domain characteristic of transposon-derived proteins and may function as a regulator of transcription. Alternative splicing occurs between a splice site from exon 5 of the adjacent upstream gene 'excision repair cross-complementation group 6' (ERCC6, GeneID: 2074) and the 3' splice site upstream of the open reading frame (ORF) of this gene, which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene. Pseudogenes for this gene are defined on chromosomes 4, 5 and 12. [provided by RefSeq, Mar 2016]
