The PGAP2 Polyclonal Antibody (PACO48142) is a valuable tool for researchers studying PGAP2, a protein involved in glycosylphosphatidylinositol (GPI) anchor biosynthesis. This antibody, generated in rabbits, exhibits high specificity and sensitivity for PGAP2 in human samples, making it suitable for Western blot applications. By binding to the PGAP2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in molecular biology and biochemistry.PGAP2 is a crucial enzyme involved in the biosynthesis of GPI anchors, which are important for anchoring membrane proteins.
Dysregulation of PGAP2 has been linked to disorders such as hyperphosphatasia with mental retardation syndrome and intellectual disabilities. Hence, research on PGAP2 is essential for understanding the mechanisms underlying these disorders and potentially developing targeted therapeutic strategies.By utilizing the PGAP2 Polyclonal Antibody, researchers can further explore the role of PGAP2 in GPI anchor biosynthesis and its implications for human health. This antibody is a valuable tool for advancing knowledge in the field of molecular biology and uncovering potential avenues for therapeutic interventions.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO48142 at dilution of 1:100.
Immunofluorescent analysis of MCF-7 cells using PACO48142 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO48142 at dilution of 1:100.
Background:
Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity).
Synonyms:
Post-GPI attachment to proteins factor 2 (FGF receptor-activating protein 1), PGAP2, FRAG1
UniProt Protein Function:
PGAP2: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface. Belongs to the PGAP2 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 11p15.5Cellular Component: Golgi membrane; endoplasmic reticulum membrane; integral to membrane; nucleusMolecular Function: protein transporter activityBiological Process: protein transport; DNA damage response, signal transduction; GPI anchor biosynthetic process; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
