The PGA5 Polyclonal Antibody (CAB12951) is a valuable tool for researchers studying the PGA5 protein, an enzyme involved in proteasome-mediated protein degradation. This antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it ideal for use in Western blot applications. By targeting the PGA5 protein, this antibody enables the detection and analysis of PGA5 expression in various cell types, providing insights into its role in cellular processes and disease pathways.PGA5, a key player in the ubiquitin-proteasome system, is critical for maintaining protein homeostasis and regulating cell function.
Dysregulation of PGA5 has been implicated in various diseases, including neurodegenerative disorders and cancer. Therefore, studying the function and expression of PGA5 is essential for advancing our understanding of these conditions and identifying potential therapeutic targets.Overall, the PGA5 Polyclonal Antibody is a valuable tool for researchers interested in investigating the role of PGA5 in protein degradation pathways and its implications in disease pathology. Its high specificity and sensitivity make it a reliable option for studying PGA5 expression and function in various experimental settings.
Product Name:
PGA5 Rabbit Polyclonal Antibody
SKU:
CAB12951
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 63-180 of human PGA5 (NP_055039.1).
This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer.
Purification Method:
Affinity purification
Gene ID:
5222
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PGA5 Rabbit pAb (CAB12951) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
