PGA3/PGA4/PGA5 Antibody (PACO18355)
- SKU:
- PACO18355
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PGA3/PGA4/PGA5 Antibody (PACO18355)
The PGA3/PGA4/PGA5 Antibody (PAC018355) is a polyclonal antibody specifically designed for research involving the PGA3, PGA4, and PGA5 proteins. These proteins are essential components of the proteasome, a complex molecular machine responsible for degrading unneeded or damaged proteins within the cell. The antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications.This antibody enables the detection and analysis of PGA3, PGA4, and PGA5 proteins in various cell types, making it an invaluable tool for researchers studying protein degradation pathways, cellular homeostasis, and diseases linked to proteasome dysfunction.
The proteasome is involved in numerous cellular processes, including cell cycle regulation, immune response, and protein quality control. Dysfunction of the proteasome has been implicated in diseases such as cancer, neurodegenerative disorders, and autoimmune conditions.By elucidating the role of PGA3, PGA4, and PGA5 proteins in proteasome function, researchers can gain insight into the mechanisms underlying these diseases and potentially identify new therapeutic targets. Understanding how these proteins contribute to cellular health and disease pathology is essential for the development of novel treatments that target the proteasome and its associated pathways.
| Antibody Name: | PGA3/PGA4/PGA5 Antibody (PACO18355) |
| Antibody SKU: | PACO18355 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:1000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human PGA3/PGA4/PGA5 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18355(PGA3/PGA4/PGA5 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 10%SDS-PAGE, Lysate: 60 μg, Lane: Human liver cancer tissue, Primary antibody: PACO18355(PGA3/PGA4/PGA5 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO18355(PGA3/PGA4/PGA5 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The genes coding for human pepsinogen (PGA3/PGA4/PGA5, PGA4, and PGA5) were assigned to chromosome region 11q13 by in situ hybridization. Previously we localized the PGA gene complex to a centromeric region of chromosome 11 (p11----q13) by Southern blot analysis of mouse-human somatic cell hybrids. Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. |
| Synonyms: | Pepsinogen 3/Pepsinogen 4/Pepsinogen 5, group I (pepsinogen A) |
| UniProt Protein Function: | PGA3: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. Belongs to the peptidase A1 family. |
| UniProt Protein Details: | Protein type:EC 3.4.23.1; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11q12.2 Molecular Function:aspartic-type endopeptidase activity Biological Process: digestion; proteolysis |
| NCBI Summary: | This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015] |
| UniProt Code: | P0DJD8 |
| NCBI GenInfo Identifier: | 378521956 |
| NCBI Gene ID: | 643834 |
| NCBI Accession: | P0DJD8.1 |
| UniProt Related Accession: | P0DJD8 |
| Molecular Weight: | |
| NCBI Full Name: | Pepsin A-3 |
| NCBI Synonym Full Names: | pepsinogen 3, group I (pepsinogen A) |
| NCBI Official Symbol: | PGA3Â Â |
| NCBI Protein Information: | pepsin A-3 |
| UniProt Protein Name: | Pepsin A-3 |
| UniProt Synonym Protein Names: | Pepsinogen-3 |
| UniProt Gene Name: | PGA3Â Â |
| UniProt Entry Name: | PEPA3_HUMAN |
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