The PFN4 Polyclonal Antibody (CAB13692) is specifically designed for research involving PFN4, a protein involved in regulating actin dynamics and cell motility. The antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in various applications, including Western blotting.PFN4, also known as Profilin-4, plays a crucial role in promoting actin polymerization and cytoskeletal rearrangement, essential processes for cell movement and division. Its role in regulating the dynamics of actin filaments makes it a key player in processes such as cell migration, intracellular trafficking, and cell shape maintenance.
Research on PFN4 is significant in understanding cellular processes such as metastasis, immune cell function, and neurodegenerative diseases where actin dynamics play a critical role. The PFN4 Polyclonal Antibody enables detection and analysis of PFN4 in various cell types, making it ideal for studies in cell biology, cancer research, and neurology. Understanding the function of PFN4 can lead to new insights into disease mechanisms and potential therapeutic targets.
Product Name:
PFN4 Rabbit Polyclonal Antibody
SKU:
CAB13692
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-129 of human PFN4 (NP_955378.1).
Predicted to enable actin monomer binding activity. Predicted to be involved in sequestering of actin monomers. Predicted to be located in cytoskeleton. Predicted to be active in cell cortex.
Purification Method:
Affinity purification
Gene ID:
375189
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PFN4 Rabbit pAb (CAB13692) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 5min.
