The PFKFB3 Rabbit Monoclonal Antibody (CAB3934) is a versatile tool for researchers studying PFKFB3, an enzyme that plays a key role in glycolysis and cell metabolism. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for a variety of research applications.PFKFB3 is known to be overexpressed in various types of cancer, where it promotes tumor growth and survival by facilitating metabolic reprogramming. By targeting PFKFB3 with this antibody, researchers can investigate its role in cancer progression and potentially identify new therapeutic targets for cancer treatment.This antibody is validated for use in Western blotting, immunohistochemistry, and other immunological techniques, enabling researchers to analyze PFKFB3 expression levels in different cell types and tissue samples.
Its reliability and performance make it an essential tool for studies in cancer biology, metabolism, and drug discovery.Overall, the PFKFB3 Rabbit Monoclonal Antibody (CAB3934) is a valuable resource for researchers seeking to explore the role of PFKFB3 in cancer and other metabolic disorders. Its high quality and specificity make it a trusted tool for advancing scientific knowledge in the field of cell metabolism and cancer research.
Product Name:
PFKFB3 Rabbit Monoclonal Antibody
SKU:
CAB3934
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human PFKFB3 (NP_004557.1).
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5209
Clone Number:
ARC50569
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using PFKFB3 Rabbit mAb (CAB3934) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
