PFKFB3 Rabbit Polyclonal Antibody (CAB6945)
- SKU:
- CAB6945
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | PFKFB3 Rabbit Polyclonal Antibody |
SKU: | CAB6945 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-220 of human PFKFB3 (NP_004557.1). |
Sequence: | TRER RHMI LHFA KEND FKAF FIES VCDD PTVV ASNI MEVK ISSP DYKD CNSA EAMD DFMK RISC YEAS YQPL DPDK CDRD LSLI KVID VGR |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 |
Synonyms: | PFK2; IPFK2; iPFK-2; PFKFB3 |
Positive Sample: | HeLa,HCT116,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, nucleoplasm |
Calculated MW: | 60kDa |
Observed MW: | 62kDa |
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5209 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |