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PFKFB2 Rabbit Polyclonal Antibody (CAB9311)

SKU:
CAB9311
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 12 Anti-PFKFB2 Antibody CAB9311
  • Cell Biology Antibodies 12 Anti-PFKFB2 Antibody CAB9311
  • Cell Biology Antibodies 12 Anti-PFKFB2 Antibody CAB9311
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:PFKFB2 Rabbit Polyclonal Antibody
SKU:CAB9311
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 446-505 of human PFKFB2 (NP_006203.2).
Sequence:RDKP TNNF PKNQ TPVR MRRN SFTP LSSS NTIR RPRN YSVG SRPL KPLS PLRA QDMQ EGAD
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200
Synonyms:PFK-2/FBPase-2; PFKFB2
Positive Sample:A-549,Mouse liver,Mouse brain,Mouse skeletal muscle,Rat liver
Conjugate:Unconjugated
Cellular Localization:cytosol, nucleoplasm
Calculated MW:58kDa
Observed MW:54kDa

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.

Purification Method:Affinity purification
Gene ID:5208
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using PFKFB2 antibody (CAB9311) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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