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PFKFB1/PFKFB4 Antibody (PACO01324)

SKU:
PACO01324
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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PFKFB1/PFKFB4 Antibody (PACO01324)

The PFKFB1/PFKFB4 Polyclonal Antibody (PACO01324) is a valuable tool for researchers studying glucose metabolism and its role in cancer and other metabolic diseases. This antibody, raised in rabbits, is highly specific for PFKFB1 and PFKFB4 proteins, which play a crucial role in the regulation of glycolysis and cell proliferation.PFKFB1 and PFKFB4 are key enzymes that control the synthesis of fructose-2,6-bisphosphate, a potent allosteric activator of 6-phosphofructo-1-kinase. This process is essential for the glycolytic pathway, which is often dysregulated in cancer cells to support their rapid growth and proliferation. By targeting these enzymes, researchers can gain valuable insights into the metabolic pathways driving tumor progression and potentially identify new therapeutic targets.

The PFKFB1/PFKFB4 Polyclonal Antibody is validated for use in Western blot applications and is highly reactive with human samples. Its ability to specifically bind to PFKFB1 and PFKFB4 proteins makes it a powerful tool for studying the role of these enzymes in cancer biology and metabolic diseases. Researchers can use this antibody to analyze protein expression levels, localization, and interactions in various cell types, advancing our understanding of glucose metabolism and its implications for human health.

Antibody Name:PFKFB1/PFKFB4 Antibody
Antibody SKU:PACO01324
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the Internal region of human PFK-2 liv/tes.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:PFKFB1; F6PK; PFRX; 6-phosphofructo-2-kinase/fructose-2; 6-bisphosphatase 1; 6PF-2-K/Fru-2,6-P2ase 1; PFK/FBPase 1; 6PF-2-K/Fru-2,6-P2ase liver isozyme; PFKFB4; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4; 6PF-2-K/Fru-2,6-P2ase 4;
UniProt Protein Function:PFKFB1: Synthesis and degradation of fructose 2,6-bisphosphate. Homodimer. Liver. Phosphorylation results in inhibition of the kinase activity.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Kinase, other; EC 3.1.3.46; Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; Phosphatase (non-protein)

Chromosomal Location of Human Ortholog: Xp11.21

Cellular Component: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex; cytosol

Molecular Function:6-phosphofructo-2-kinase activity; fructose-2,6-bisphosphate 2-phosphatase activity; identical protein binding; protein binding

Biological Process: fructose 2,6-bisphosphate metabolic process; gluconeogenesis; glycolysis

NCBI Summary:This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
UniProt Code:P16118
NCBI GenInfo Identifier:2507178
NCBI Gene ID:5207
NCBI Accession:P16118.3
UniProt Secondary Accession:P16118,Q5JXS5, Q99951, B2RA88, B4DUN5,
UniProt Related Accession:P16118
Molecular Weight:47,426 Da
NCBI Full Name:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
NCBI Synonym Full Names:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
NCBI Official Symbol:PFKFB1  
NCBI Official Synonym Symbols:F6PK; HL2K; PFRX  
NCBI Protein Information:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
UniProt Protein Name:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
UniProt Synonym Protein Names:6PF-2-K/Fru-2,6-P2ase liver isozymeIncluding the following 2 domains:6-phosphofructo-2-kinase (EC:2.7.1.105)Fructose-2,6-bisphosphatase (EC:3.1.3.46)
Protein Family:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
UniProt Gene Name:PFKFB1  
UniProt Entry Name:F261_HUMAN

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