The PF4 Polyclonal Antibody (CAB17376) is a valuable tool for research involving Platelet Factor 4 (PF4), a protein involved in blood coagulation and inflammation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By binding specifically to the PF4 protein, this antibody allows for the detection and analysis of PF4 in various cell types, making it a versatile option for studies in hemostasis, thrombosis, and inflammation.PF4 is a key regulator of blood coagulation and inflammation, playing a crucial role in the formation of blood clots and the immune response to injury and infection.
Dysregulation of PF4 has been implicated in various diseases, including thrombosis, heparin-induced thrombocytopenia, and inflammatory disorders. By studying the function and expression of PF4, researchers can gain insights into the pathophysiology of these conditions and potentially identify new therapeutic targets for intervention.Overall, the PF4 Polyclonal Antibody (CAB17376) is a reliable tool for investigating the role of PF4 in health and disease. Its specificity and sensitivity make it an essential reagent for researchers working in the fields of hematology, immunology, and cardiovascular biology.
Product Name:
CXCL4/PF4 Rabbit Polyclonal Antibody
SKU:
CAB17376
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 32-101 of human CXCL4/PF4 (NP_002610.1).
cytoplasm, extracellular region, extracellular space
Calculated MW:
11kDa
Observed MW:
10kDa
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum.
Purification Method:
Affinity purification
Gene ID:
5196
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CXCL4/PF4 antibody (CAB17376) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
