The PEX6 Polyclonal Antibody (CAB10459) is a valuable tool for researchers studying the peroxisomal biogenesis factor 6 (PEX6) protein, which plays a crucial role in peroxisome assembly and maintenance. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications.PEX6 is essential for the import of proteins into peroxisomes, organelles involved in lipid metabolism and detoxification processes. Dysregulation of PEX6 function has been implicated in peroxisome biogenesis disorders, neurodegenerative diseases, and metabolic disorders.
Understanding the role of PEX6 in peroxisome function is critical for advancing research in these areas and developing potential therapies.With its specificity for PEX6 protein detection, the PEX6 Polyclonal Antibody is an ideal tool for investigating the localization and expression of PEX6 in various cell types and tissues. Researchers in the fields of cell biology, metabolism, and neurology can benefit from using this antibody to explore the functions and dysregulation of PEX6 in health and disease.
Product Name:
PEX6 Rabbit Polyclonal Antibody
SKU:
CAB10459
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 741-980 of human PEX6 (NP_000278.3).
This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) family of ATPases. This member is a predominantly cytoplasmic protein, which plays a direct role in peroxisomal protein import and is required for PTS1 (peroxisomal targeting signal 1, a C-terminal tripeptide of the sequence ser-lys-leu) receptor activity. Mutations in this gene cause peroxisome biogenesis disorders of complementation group 4 and complementation group 6. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5190
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PEX6 antibody (CAB10459) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
