The PEX5 Polyclonal Antibody (CAB5780) is a valuable tool for researchers studying peroxisome biogenesis and function. Peroxisomes are essential organelles involved in various metabolic pathways, including fatty acid oxidation and detoxification processes. PEX5 is a key receptor protein responsible for targeting matrix proteins to the peroxisomal membrane. This polyclonal antibody, raised in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to PEX5, researchers can study the role of this receptor protein in peroxisome assembly and functionality in different cell types.
The importance of peroxisomes in maintaining cellular homeostasis and metabolism makes PEX5 a crucial target for research in various fields, including neurodegenerative disorders, metabolic diseases, and aging-related conditions. Understanding the mechanisms underlying peroxisome function and biogenesis can provide insights into potential therapeutic strategies for treating these disorders.
Product Name:
PEX5 Rabbit Polyclonal Antibody
SKU:
CAB5780
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PEX5 (NP_000310.2).
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
5830
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PEX5 Rabbit pAb (CAB5780) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Basic Kit (AbGn00020)._Exposure time: 90s.
