The PEX5 Polyclonal Antibody (CAB12493) is a valuable tool for researchers studying peroxisomal biogenesis and protein import. PEX5 is a key receptor protein involved in the targeting and import of peroxisomal matrix proteins. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.By binding to PEX5, this antibody allows for the detection and analysis of this important protein in various cell types, facilitating research in areas such as metabolism, lipid homeostasis, and cellular detoxification.
Understanding the function and regulation of PEX5 is crucial for advancing our knowledge of peroxisome biogenesis and its implications for human health and disease.Whether investigating peroxisomal disorders, lipid metabolism, or cellular signaling pathways, the PEX5 Polyclonal Antibody is a valuable tool for researchers looking to explore the complex biology of peroxisomes and their role in various cellular processes.
Product Name:
PEX5 Rabbit Polyclonal Antibody
SKU:
CAB12493
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 364-631 of human PEX5 (NP_000310.2).
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
5830
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PEX5 Rabbit pAb (CAB12493) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
