PEX5 Rabbit Polyclonal Antibody (CAB12493)
- SKU:
- CAB12493
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | PEX5 Rabbit Polyclonal Antibody |
SKU: | CAB12493 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 364-631 of human PEX5 (NP_000310.2). |
Sequence: | WQYL GTTQ AENE QELL AISA LRRC LELK PDNQ TALM ALAV SFTN ESLQ RQAC ETLR DWLR YTPA YAHL VTPA EEGA GGAG LGPS KRIL GSLL SDSL FLEV KELF LAAV RLDP TSID PDVQ CGLG VLFN LSGE YDKA VDCF TAAL SVRP NDYL LWNK LGAT LANG NQSE EAVA AYRR ALEL QPGY IRSR YNLG ISCI NLGA HREA VEHF LEAL NMQR KSRG PRGE GGAM SENI WSTL RLAL SMLG QSDA YGAA DARD LSTL LTMF GLPQ |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | PXR1; PBD2A; PBD2B; PTS1R; RCDP5; PTS1-BP; PEX5 |
Positive Sample: | U-251MG,HepG2,293T,HeLa,Mouse brain,Mouse kidney,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Peripheral membrane protein, Peroxisome membrane. |
Calculated MW: | 71kDa |
Observed MW: | 71kDa |
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method: | Affinity purification |
Gene ID: | 5830 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |