The PEX19 Polyclonal Antibody (CAB5476) is a valuable tool for researchers studying the peroxisome biogenesis factor 19 (PEX19) protein. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the PEX19 protein, this antibody allows for easy detection and analysis of PEX19 in various cell types, making it ideal for studies in cell biology and genetics.PEX19 is a crucial player in the formation and maintenance of peroxisomes, organelles involved in lipid metabolism and reactive oxygen species detoxification. Dysregulation of peroxisome biogenesis has been linked to various genetic disorders and metabolic diseases.
Research on PEX19 can provide insights into the mechanisms underlying these conditions and potentially lead to the development of novel therapeutic strategies.By utilizing the PEX19 Polyclonal Antibody, researchers can further their understanding of peroxisome biogenesis and its implications in human health. Whether investigating inherited peroxisomal disorders or studying the role of peroxisomes in cellular homeostasis, this antibody offers a reliable tool for accurate and reproducible experimental results.
Product Name:
PEX19 Rabbit Polyclonal Antibody
SKU:
CAB5476
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-299 of human PEX19 (NP_002848.1).
This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5824
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PEX19 antibody (CAB5476) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
