The PEX14 Polyclonal Antibody (CAB7336) is an essential tool for researchers studying peroxisomal biogenesis and function. PEX14 is a key peroxisomal membrane protein that plays a critical role in the import of proteins into the peroxisome, as well as in peroxisome proliferation and maintenance.This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It specifically targets the PEX14 protein, allowing for the detection and analysis of PEX14 expression levels in various cell types and tissues.
Research involving peroxisomes is crucial for understanding various metabolic pathways, including fatty acid oxidation and ether lipid synthesis. Dysregulation of peroxisomal function has been implicated in a variety of human diseases, including peroxisomal biogenesis disorders and neurodegenerative diseases.Overall, the PEX14 Polyclonal Antibody is a valuable tool for researchers investigating the role of peroxisomes in health and disease, and may contribute to the development of novel therapeutic approaches targeting peroxisomal dysfunction.
Product Name:
PEX14 Rabbit Polyclonal Antibody
SKU:
CAB7336
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 118-377 of human PEX14 (NP_004556.1).
This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.
Purification Method:
Affinity purification
Gene ID:
5195
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse kidney, using PEX14 Rabbit pAb (CAB7336) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
