The PEX12 Polyclonal Antibody (CAB16062) is a valuable tool for research involving PEX12, a peroxisomal biogenesis factor essential for peroxisome assembly and function. This antibody, produced in rabbits, is highly specific for detecting PEX12 in human samples and has been validated for use in Western blot and immunofluorescence applications.PEX12 is a key player in the biogenesis of peroxisomes, organelles essential for lipid metabolism, cellular detoxification, and redox balance. Dysregulation of peroxisome function has been linked to various metabolic disorders, neurodegenerative diseases, and cancer.
By targeting PEX12 with this antibody, researchers can gain insights into peroxisome biology and its implications in health and disease.This PEX12 Polyclonal Antibody is a valuable tool for studies in cell biology, biochemistry, and molecular biology, enabling researchers to investigate the role of PEX12 in peroxisome biogenesis and function. Its high specificity and sensitivity make it an excellent choice for elucidating the molecular mechanisms underlying peroxisome-related disorders and exploring potential therapeutic strategies targeting peroxisome function.
Product Name:
PEX12 Rabbit Polyclonal Antibody
SKU:
CAB16062
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 290-359 of human PEX12 (NP_000277.1).
This gene belongs to the peroxin-12 family. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS).
Purification Method:
Affinity purification
Gene ID:
5193
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PEX12 Rabbit pAb (CAB16062) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
