The PEX1 Polyclonal Antibody (PACO11172) is a valuable tool for research involving PEX1, a peroxisomal biogenesis factor involved in the formation and function of peroxisomes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the PEX1 protein, it facilitates the detection and analysis of PEX1 in various cell types, making it ideal for studies in cell biology and metabolism research.
PEX1 is essential for peroxisome biogenesis and dysfunction in this pathway is associated with severe peroxisomal disorders, such as Zellweger syndrome. Understanding the function and regulation of PEX1 is crucial for advancing research into peroxisomal disorders and developing potential therapies. The PEX1 Polyclonal Antibody offers researchers a reliable tool for investigating the role of PEX1 in peroxisome biology and related diseases.
This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
