The PES1 Polyclonal Antibody (CAB14506) is a valuable tool for researchers studying the PES1 protein, a component of the Pescadillo ribosomal biogenesis factor 1 complex. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the PES1 protein, this antibody allows for accurate detection and analysis in various cell types, making it ideal for investigations in molecular biology and cancer research.PES1 is a key player in ribosome biogenesis and is associated with cellular proliferation and tumorigenesis.
Its involvement in essential cellular processes makes it a promising target for understanding cancer development and identifying potential therapeutic interventions. The PES1 Polyclonal Antibody provides researchers with a reliable tool for exploring the function and regulation of PES1 in various physiological and pathological conditions, contributing to advancements in cancer biology and drug discovery efforts.
Product Name:
PES1 Rabbit Polyclonal Antibody
SKU:
CAB14506
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human PES1 (NP_055118.1).
This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9.
Purification Method:
Affinity purification
Gene ID:
23481
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PES1 Rabbit pAb (CAB14506) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
