The Peroxiredoxin-3 Rabbit Monoclonal Antibody (CAB2398) is a highly specific research tool designed for the detection and analysis of Peroxiredoxin-3, a key protein involved in antioxidant defense and redox signaling. This antibody, produced in rabbits, exhibits high reactivity with Peroxiredoxin-3 in human samples and is validated for use in Western blot applications.Peroxiredoxin-3 is a vital enzyme located in the mitochondria that plays a crucial role in protecting cells from oxidative damage and maintaining cellular redox balance. Dysregulation of Peroxiredoxin-3 has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.
Studying the expression and function of Peroxiredoxin-3 using this antibody can provide valuable insights into the mechanisms underlying these pathologies.By enabling precise detection and quantification of Peroxiredoxin-3 in different cell types and tissues, this monoclonal antibody is an essential tool for researchers investigating oxidative stress, redox biology, and mitochondrial function. Its reliability and specificity make it an ideal choice for studies focused on understanding the role of Peroxiredoxin-3 in health and disease.
This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22.
Purification Method:
Affinity purification
Gene ID:
10935
Clone Number:
ARC0747
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Peroxiredoxin 3 (PRDX3) (PRDX3) Rabbit mAb (CAB2398) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
