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Peroxiredoxin 3 (PRDX3) Polyclonal Antibody (CAB21341)

SKU:
CAB21341
$155
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Description

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Product Name:Peroxiredoxin 3 (PRDX3) Polyclonal Antibody
SKU:CAB21341
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Rat
Immunogen:Recombinant Protein corresponding to a sequence within amino acids 63-256 of human Peroxiredoxin 3 (PRDX3) (NP_006784.1).
Sequence:PAVT QHAP YFKG TAVV NGEF KDLS LDDF KGKY LVLF FYPL DFTF VCPT EIVA FSDK ANEF HDVN CEVV AVSV DSHF SHLA WINT PRKN GGLG HMNI ALLS DLTK QISR DYGV LLEG SGLA LRGL FIID PNGV IKHL SVND LPVG RSVE ETLR LVKA FQYV ETHG EVCP ANWT PDSP TIKP SPAA SKEY FQKV NQ
Tested Applications:WB ELISA
Recommended Dilution:WB,1:1000 - 1:5000
Synonyms:AOP1; MER5; AOP-1; PPPCD; SP-22; HBC189; SCAR32; PRO1748; prx-III; Peroxiredoxin 3 (PRDX3)
Positive Sample:U-87 MG,HeLa,L-02,A549,Rat kidney
Conjugate:Unconjugated
Cellular Localization:Mitochondrion.
Calculated MW:28kDa
Observed MW:28kDa

This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22.

Purification Method:Affinity purification
Gene ID:10935
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using Peroxiredoxin 3 (PRDX3) Rabbit pAb (CAB21341) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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