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PerCP/Cyanine5.5 Anti-Rat CD44H Antibody [OX-49] (AGEL2435)

SKU:
AGEL2435
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Rat
Host Species:
Mouse
Isotype:
Mouse IgG2a, κ
Clone:
OX-49
Conjugation:
PerCP/Cyanine5.5
€229 - €549
Frequently bought together:

Description

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PerCP/Cyanine5.5 Anti-Rat CD44H Antibody [OX-49]

The PERCP-Cyanine5.5 Anti-Rat CD44H Antibody (OX-49) is a crucial tool for researchers studying CD44H, a cell surface glycoprotein involved in cell adhesion, migration, and signaling processes. This antibody, specifically designed for use in rat samples, has been developed to target the CD44H protein with high specificity and sensitivity. Validated for flow cytometry applications, it enables precise detection and analysis of CD44H expression in various cell types, making it an essential reagent for studies in immunology, cell biology, and cancer research.CD44H is a multifunctional molecule found on the surface of many cell types, including immune cells and cancer stem cells, where it plays a pivotal role in mediating cell-cell interactions, cell migration, and signaling cascades.

Due to its involvement in diverse cellular processes, CD44H is a key target for investigation in various research fields, including immunology and oncology. Understanding the expression and function of CD44H is crucial for unraveling its roles in cancer progression, immune responses, and cellular communication pathways, offering valuable insights for the development of novel therapeutic strategies in cancer and other diseases.

Product Title:PerCP/Cyanine5.5 Anti-Rat CD44H Antibody [OX-49]
SKU:AGEL2435
Size:25µg, 100µg
Clone No:OX-49
Synonyms:Pgp-1; H-CAM; CD44s;CD44H;
Host Species:Mouse
Reactivity:Rat
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:PerCP/Cyanine5.5 Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:PerCP/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P26051
Gene ID:12505
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD44 is an 80-95 kD cell surface glycoprotein. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. It is up-regulated when T cells and B cells are activated. It was reported that CD44 is a valuable marker for memory T cells. CD44 is an adhesion molecule involved in leukocyte adhesion and homing to lymphoid organs. The OX-49 antibody reacts with CD44H (known as CD44s) expressed on most leukocytes, except for a subset of B lymphocytes. The epitope recognized by OX-49 antibody has been mapped to a region on both the standard, CD44s, and the splice variant, CD44v, isoforms of CD44. However it was reported that OX-49 antibody cannot detect the CD44V isoform, possibly due to conformational changes in the epitope.

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