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PerCP/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody [29F.1A12] (AGEL2258)

SKU:
AGEL2258
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, κ
Clone:
29F.1A12
Conjugation:
PerCP/Cyanine5.5
$287 - $647
Frequently bought together:

Description

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PerCP/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody [29F.1A12]

The PERCP-cyanine5.5 Anti-Mouse CD279 (PD-1) Antibody (29F.1A12) is a potent tool for research aimed at studying the PD-1 protein, a key regulator of immune checkpoints. This antibody, developed for use in mouse samples, is monoclonal in nature and has been extensively validated for flow cytometry applications. By specifically binding to PD-1, this antibody allows for precise detection and analysis of PD-1 expression in various immune cell populations, making it an ideal choice for investigations in immunology, oncology, and other related fields.PD-1, also known as programmed cell death protein 1, plays a crucial role in immune system regulation by modulating T-cell responses and preventing excessive immune activation.

Its involvement in immune tolerance and evasion mechanisms has made it a prominent target for research in cancer immunotherapy and other immune-related diseases. Understanding the function and expression of PD-1 is essential for developing innovative treatments that enhance immune responses or overcome immune evasion strategies in diseases such as cancer and autoimmune disorders.

Product Title:PerCP/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody [29F.1A12]
SKU:AGEL2258
Size:25µg, 100µg
Clone No:29F.1A12
Synonyms:PD-1; Programmed Death-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PerCP/Cyanine5.5 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PerCP/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q02242
Gene ID:18566
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

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